Modification of the cysteamine side chain of thienamycin. III.
نویسندگان
چکیده
Thienamycin derivatives (4) having a cyclic amidine moiety at the C-2 position were prepared. The susceptibility to renal dehydropeptidase-1 and the antimicrobial activity of these compounds were determined. Their structure-activity relationships are also discussed.
منابع مشابه
Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis.
The enzymatic activities of three proteins encoded by the thienamycin gene cluster of Streptomyces cattleya (ThnR, ThnH, and ThnT) have been shown to incrementally cleave CoA to afford the active side-chain component of the beta-lactam antibiotic thienamycin. These results supersede proposals based on earlier radiochemical incorporation experiments. For 20 years it has been thought that cystein...
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Radioactiveand stable isotope-containing substrates were used to identify the biosynthetic precursors of the &lactam antibiotic, thienamycin, in Streptomyces cattleya. Acetate is utilized by the organism to form C(6) and C(7) of the &lactam ring. The two carbons of the hydroxyethyl group attached to C(6) are both derived from the methyl of methionine. The cysteaminyl side chain attached to C(2)...
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عنوان ژورنال:
- The Journal of antibiotics
دوره 40 4 شماره
صفحات -
تاریخ انتشار 1987